| Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α | |
| 論文作者 | Xia, JL; Chen, H; Wang, XX; Chen, WX; Lin, J; Xu, F; Nie, QX; Ye, C; Zhong, BT; Zhao, M; Yun, CY; Zeng, GY; Mao, YJ; Wen, YP; Zhang, XG; Yan, S; Wang, XM; Sun, LL; Liu, F; Zhong, C; Xia, PY; Jiang, CT; Rao, HY; Pang, YL |
| 期刊/會(huì)議名稱 | NATURE COMMUNICATIONS |
| 論文年度 | 2024 |
| 論文類別 | |
| 摘要 | Non-alcoholic steatohepatitis (NASH) is a severe type of the non-alcoholic fatty liver disease (NAFLD). NASH is a growing global health concern due to its increasing morbidity, lack of well-defined biomarkers and lack of clinically effective treatments. Using metabolomic analysis, the most significantly changed active lipid sphingosine d18:1 [So(d18:1)] is selected from NASH patients. So(d18:1) inhibits macrophage HIF-2 alpha as a direct inhibitor and promotes the inflammatory factors secretion. Male macrophage-specific HIF-2 alpha knockout and overexpression mice verified the protective effect of HIF-2 alpha on NASH progression. Importantly, the HIF-2 alpha stabilizer FG-4592 alleviates liver inflammation and fibrosis in NASH, which indicated that macrophage HIF-2 alpha is a potential drug target for NASH treatment. Overall, this study confirms that So(d18:1) promotes NASH and clarifies that So(d18:1) inhibits the transcriptional activity of HIF-2 alpha in liver macrophages by suppressing the interaction of HIF-2 alpha with ARNT, suggesting that macrophage HIF-2 alpha may be a potential target for the treatment of NASH. Non-alcoholic steatohepatitis has with few well-defined biomarkers or clinically effective treatments but is promoted by inflammation. Here, the authors find an active lipid [So(d18:1)] that is significantly changed in patients and promotes inflammation by directly inhibiting macrophage HIF-2 alpha. |
| 期 | 1 |
| 卷 | 15 |
| 影響因子 | 14.7 |
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