郵箱: ykyao@sinh.ac.cn
電話: +86-21-54920250
所屬部門: 腫瘤與微環(huán)境重點(diǎn)實(shí)驗(yàn)室
2023.04-至 今：中國科學(xué)院上海營養(yǎng)與健康研究所 研究員
2017.04-2022.12：National Institutes of Health 博士后
2013.08-2017.03：中國科學(xué)院上海生命科學(xué)研究院 博士后
2008.09-2013.09：中國科學(xué)院上海生命科學(xué)研究院 博士
免疫系統(tǒng)調(diào)控與炎癥性疾病
免疫系統(tǒng)功能的正常維持是保證機(jī)體健康的必要條件。本實(shí)驗(yàn)室通過遺傳學(xué)、細(xì)胞生物學(xué)、分子生物學(xué)、微生物學(xué)和計算生物學(xué)等多學(xué)科技術(shù)手段來理解和擴(kuò)展免疫系統(tǒng)如何參與疾病進(jìn)程。通過遺傳修飾小鼠、疾病模型和臨床病人來闡析免疫系統(tǒng)的失調(diào)如何導(dǎo)致免疫缺陷、自身免疫、炎癥、過敏、慢性感染等重大疾病，重點(diǎn)關(guān)注黏膜免疫及抗腫瘤免疫。并基于前期分子機(jī)理研究，為腸道等慢性黏膜炎癥類疾病和腫瘤的免疫治療開發(fā)新型診斷與治療途徑。主要研究方向包括（1）腸道黏膜免疫的分子調(diào)控機(jī)制；（2）腫瘤細(xì)胞外基質(zhì)與抗腫瘤免疫；（3）人類單基因遺傳病的致病機(jī)理。
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