郵箱: abwu@sinh.ac.cn
電話: +86-21-54920926
所屬部門: 營養(yǎng)代謝與食品安全重點實驗室
2017-至 今：中國科學(xué)院上海營養(yǎng)與健康研究所，研究員
2015-2016年：中國科學(xué)院上海生命科學(xué)研究院營養(yǎng)科學(xué)研究所，研究員
2013-2014年：上海市農(nóng)業(yè)科學(xué)院，農(nóng)產(chǎn)品質(zhì)量標準與檢測技術(shù)研究所，研究員
2011-2012年：上海市農(nóng)業(yè)科學(xué)院，農(nóng)產(chǎn)品質(zhì)量標準與檢測技術(shù)研究所，副研究員
2009-2011年：每年1個月，比利時根特大學(xué)、法魯汶大學(xué)，合作研究
2007-2010年：上海交通大學(xué)，生命科學(xué)技術(shù)學(xué)院，副教授
2005-2007年：上海交通大學(xué)，生命科學(xué)技術(shù)學(xué)院，講師
真菌毒素危害與控制
1. 采用細胞、類器官、動物、特定隊列人群等評價鐮刀菌、鏈格孢菌等毒素及其隱蔽型污染的（聯(lián)合）毒性作用及干預(yù)功效，揭示毒性新靶點與減控新機制。
2. 研究鐮刀菌、鏈格孢菌等真菌毒素污染發(fā)生的調(diào)控與生物降解毒素的關(guān)鍵新基因及其功能，解析相關(guān)分子識別機制，研發(fā)菌劑、酶制劑等控制產(chǎn)品，制定真菌毒素污染安全控制規(guī)范。
3. 研發(fā)真菌毒素與食品安全相關(guān)定性定量檢測方法、標準品、風(fēng)險監(jiān)測與評估及營養(yǎng)健康產(chǎn)品（合成生物食品、食藥同源物質(zhì)或特定配方等）功效評價體系等，為政府部門、企業(yè)等食品安全監(jiān)管與內(nèi)控提供解決方案。
1.?He WJ, Xiong RY, Zheng MR, Tang MH, Zhang TT, Zhang YS, Wang Q, Zhao CX, Huang T, Liu YK, Tian Y, Karim M. Tabl, Mao XM, Li P, Feng GW, Bai XC, Liu Q, Yan WH, Liao YC, Zhang JB*, Yin P*, Wu AB*. Specialized aldo-keto reductases trigger complete degradation of mycotoxin deoxynivalenol. Nature Communications 2026; https://doi.org/10.1038/s41467-026-70007-z.
2.?Yi XL, Tan YZ, Lin HK, Zhang GQ, Tian Y*, Wu AB*. CACLENS: A Multitask Deep Learning System for Enzyme Discovery. Advanced Science 2025, e18063. https://doi.org/10.1002/advs.202518063.
3.?Wang SY, Shen SQ, Kang SM, Yan Z, Wu SJ, Liu N, Wu AB*. Magnet regulating valve reconstructed lab-on-a-disc POCT system. Biosensors and Bioelectronics 2026, 294.
4.?Tian Y#, Zhang DC#, Xing HD, He WJ, Liu DL, Lin HK, Yan WH, Hu QN*, Wu AB*. Computational glycosyltransferases masked deoxynivalenol toxicity and halted FHB spread in wheat grains. Journal of Advanced Research 2025,https://doi.org/10.1016/j.jare.2025.08.045.
5.?Sun F#, Fan YY#, Dai YY#, Tang MH, Du JT, Xu AQ, Liu MC, Chu QQ, Yu DZ, Tian Y, Sun XY, Ren WH, Cai PL, Yan Z, Saeger S, Wang C, Wu AB*. Elucidating the occurrence patterns of Alternaria toxin tenuazonic acid in individual tomatoes through MALDI-MSI and LC-MS/MS. Food Chem 2025;488,144912.
6.?Zhao YR#, Wang L#, Zeng R, Chen PR, Xu KH，Huang XM, Wu AB*. Sterigmatocystin in rice through LC-MS/MS: Longitudinal study on contamination, health risks and residual patterns in China. Food Chem 2025;487,144814.
7.?Zhang YQ, Lin HK, Wang L, He LJ, Man Y, Jia BX, Yan Z, Kang SM, Xie HJ, Wu AB*. Modulating the electronic configuration of single-atom nanozymes using cobalt nanoclusters for enhanced mycotoxin degradation. Food Chem 2025;479,143852.
8.?Wang ZL, Liu N, Wu AB*. Ultrasensitive colorimetric detection of deoxynivalenol in infant milk powder based on the inhibitory effect of silver ions on the peroxidase-likeactivity of Ni@Pt nanoparticles. Food Chem 2025;472,142947.
8.?Sun ST, Yu DZ, Guo MZ, Tang MH, Yan Z, Sun W, Wu AB*. The transcription factor FgSfp1 orchestrates mycotoxin deoxynivalenol biosynthesis in Fusarium graminearum. Commun Biol 2024 Nov 27;7(1):1584.
9.?Zhang DC#, Xing HD#, Liu DL#, Han MY, Cai PL, Lin HK, Tian Y, Guo YH, Sun B, Le YY, Tian Y*, Wu AB*, Hu QN*. Discovery of Toxin-Degrading Enzymes with Positive Unlabeled Deep Learning. ACS Catalysis 2024;14:3336–3348.
10.?Jia BX, Lin HK, Yu S, Liu N, Yu DZ, Wu AB*. Mycotoxin deoxynivalenol-induced intestinal flora disorders, dysfunction and organ damage in broilers and pigs. Journal of Hazardous Materials 2023 Mar 7;451:131172.
11.?Lin HK, Jia BX, Wu AB*. Cytotoxicities of Co-occurring alternariol, alternariol monomethyl ether and tenuazonic acid on human gastric epithelial cells. Food and Chemical Toxicology 2023 Jan;171:113524.
12.?Zhou HY, Sun F, Lin HK, Fan YY, Wang C, Yu DZ, Liu N, Wu AB*. Food bioactive compounds with prevention functionalities against fungi and mycotoxins: developments and challenges. Current Opinion in Food Science 2022 Dec;48:100916.
13.?Tian Y, Abdallah M. F, De Boevre M, Audenaert K, Wang C, De Saeger S, Wu AB*. Deciphering Alternaria metabolic responses in microbial confrontation via an integrated mass spectrometric targeted and non-targeted strategy. Food Chemistry 2022 Oct 20;404(Pt B):134694.
14.?Sun F, Yu DZ, Zhou HY, Lin HK, Yan Z, Wu AB*. CotA laccase from Bacillus licheniformis ZOM-1 effectively degrades zearalenone, aflatoxin B1 and alternariol. Food Control 2022 Oct;145(2):109472.
15.?Wang JH, Lin SH, Zhu GH, Zhao ZY, Wang HY, Zhou MP, Zhao XM, Wu AB*. Identification of Candidate Genes Associated with Trichothecene Biosynthesis in Fusarium graminearum Species Complex Combined with Transcriptomic and Proteomic Analysis. Microorganisms 2022 Jul 22;10(8):1479.
16.?Wang L, Yan Z, Zhao QY, Liu N, Yu DZ, Jia BX, Li KL, Gao Y, Wu AB*. A prospective study of total urinary deoxynivalenol in adolescents in Shanghai, China. Chemosphere 2022 Jul 18:135727.
17.?Li KL, Yu DZ, Yan Z, Liu N, Fan YY, Wang C, Wu AB*. Exploration of Mycotoxin Accumulation and Transcriptomesof Different Wheat Cultivars duringFusarium graminearum Infection. Toxins 2022 Jul 13;14(7):482.
18.?Tian Y, Zhang DC, Cai PL, Lin HK, Ying H, Hu QN*, Wu AB*. Elimination of Fusarium mycotoxin deoxynivalenol (DON) via microbial and enzymatic strategies: current status and future perspectives. Trends in Food Science and Technology 2022 Jun;124:96-107.
19.?Sun F, Cao XQ, Yu DZ, Hu DQ, Yan Z, Fan YY, Wang C, Wu AB*. AaTAS1 and AaMFS1 genes for biosynthesis or efflux transport of tenuazonic acid and pathogenicity of Alternaria alternata. Molecular Plant-Microbe Interactions 2022 May;35(5):416-427.
20.?Li KL, Yu S, Yu DZ, Lin HK, Liu N, Wu AB*. Biodegradation of fumonisins by the consecutive action of a fusion enzyme. Toxins 2022 Apr;14(4):266.
21.?Yu S, Jia BX, Lin HK, Zhang S, Yu DZ, Liu N, Wu AB*. Effects of Fumonisin B and Hydrolyzed Fumonisin B on Growth and Intestinal Microbiota in Broilers. Toxins 2022 Mar;14(3):163.
22.?Li KL, Wang L, Yu DZ, Yan Z, Liu N, Wu AB*. Cellobiose inhibits the release of deoxynivalenol from transformed deoxynivalenol-3-glucoside from Lactiplantibacillus plantarum. Food Chemistry: Molecular Sciences 2022 Jan 20;4:100077.
23.?Jia BX, Yu S, Yu, DZ, Liu N, Zhang S, Wu AB*. Mycotoxin deoxynivalenol affects myoblast differentiation via downregulating cytoskeleton and ECM-integrin-FAK-RAC-PAK signaling pathway. Ecotoxicology and Environmental Safety 2021 Oct 1;226:112850.
24.?Wang L, Yan Z, Zhou HY, Fan YY, Wang C, Zhang JB, Liao YC, Wu AB*. Validation of LC-MS/MS Coupled with a Chiral Column for the Determination of 3- or 15-Acetyl Deoxynivalenol Mycotoxins from Fusarium graminearum in Wheat. Toxins 2021 Sep 16;13(9):659.
25.?Yu S, Jia BX, Liu N, Yu DZ, Zhang S, Wu AB*. Fumonisin B1 triggers carcinogenesis via HDAC/PI3K/Akt signaling pathway in human esophageal epithelial cells. Science of the Total Environmental 2021 Sep 15;787:147405.
26.?Zhou HY, Liu N, Yan Z, Yu DZ, Wang L, Wang KB, Wei XL, Wu AB*. Development and Validation of the One-step Purification Method Coupled to LC-MS/MS for Simultaneous Determination of Four Aflatoxins in Fermented Tea. Food Chemistry 2021 Aug 30;354:129497.
27.?Zhang DC, Tian Y, Tian Y, Xing HD, Liu S, Zhang HY, Ding SZ, Cai PL, Sun DD, Zhang T, Hong YH, Dai HK, Tu WZ, Chen JN, Wu AB*, Hu QN*. A data-driven integrative platform for computational prediction of toxin biotransformation with a case study. Journal of Hazardous Materials 2021 Apr 15;408:124810.
28.?Tian Y, Yu DZ, Liu N, Tang Y, Yan Z, Wu AB*. Confrontation assays and mycotoxin treatment reveal antagonistic activities of Trichoderma and the fate of Fusarium mycotoxins in microbial interaction. Environmental Pollution 2020 Dec;267:115559.
29.?Yu S, Jia BX, Liu N, Yu DZ, Wu AB*. Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells. International Journal of Molecular Sciences 2020 Aug 18;21(16):E5917.
30.?Yang YX, Yu S, Jia BX, Liu N, Wu AB*. Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis. Toxicology in Vitro 2020 Aug;66:104838.
31.?Yu S, Jia BX, Li KL, Zhou HY, Lai WS, Tang Y, Yan Z, Sun W, Liu N, Yu DZ, Wu AB*. Pre-warning of abiotic factors in maize required for potential contamination of fusarium mycotoxins via response surface analysis. Food Control 2020 Mar 21;121:107570.
32.?Yang XL, Zhao ZY, Tan YL, Chen B, Zhou CY, Wu AB*. Risk profiling of exposures to multiclass contaminants through cereals and cereal-based products consumption: A case study for the inhabitants in Shanghai, China. Food Control 2020 Mar;109:106964.
33.?Yu S, Jia BX, Yang YX, Liu N, Wu AB*. Involvement of PERK-CHOP pathway in fumonisin B1- induced cytotoxicity in human gastric epithelial cells. Food and Chemical Toxicology 2020 Feb;136:111080.
34.?Hu DQ, Yu S, Yu DZ, Liu N, Tang Y, Fan YY, Wang C, Wu AB*. Biogenic Trichoderma harzianum-derived selenium nanoparticles with control functionalities originating from diverse recognition metabolites against phytopathogens and mycotoxins. Food Control 2019 Dec;106:106748.
35.?Wang JH, Wang SX, Zhao ZY, Lin SH, Francois VH, Wu AB*. Species Composition and Toxigenic Potential of Fusarium Isolates Causing Fruit Rot of Sweet Pepper in China. Toxins 2019 Nov 24;11(12):690.
36.?Md Shofiul Azam, Yu DZ, Liu N, Wu AB*. Degrading Ochratoxin A and Zearalenone Mycotoxins Using a Multifunctional Recombinant Enzyme. Toxins 2019 May 27;11(5):301.
37.?Yang YX, Yu S, Liu N, Xu HB, Gong YY, Wu YN, Wang PL, Su XO, Liao YC, Sarah De Saeger S, Humpf H, Wu AB*. Transcription factor FOXO3a is a negative regulator of cytotoxicity of Fusarium mycotoxin in GES-1 cells. Toxicological Sciences 2018 Dec 1;166(2):370-381.
38.?Wang L, Zhang QY, Yan Zheng, Tan YL, Zhu RY, Yu DZ, Yang H*, Wu AB*. Occurrence and Quantitative Risk Assessment of Twelve Mycotoxins in Eggs and Chicken Tissues in China. Toxins 2018 Nov 16;10(11):477.
39.?Yan Z, Wang L, Wang J, Tan YL, Yu DZ, Chang XJ, Fan YY, Zhao DY, Wang C, De Boevre M, De Saeger Sarah, Sun CP*, Wu AB*. A QuEChERS-Based Liquid Chromatography-Tandem Mass Spectrometry Method for the Simultaneous Determination of Nine Zearalenone-Like Mycotoxins in Pigs. Toxins 2018 Mar 20;10(3):129.
40.?Tian Y, Tan YL, Yan Z, Liao YC, Chen J, Marthe De Boevre, Sarah De Saeger, Aibo Wu*. Antagonistic and Detoxification Potentials of Trichoderma Isolates for Control of Zearalenone (ZEN) Producing Fusarium graminearum. Frontiers in Microbiology 2018 Jan 18;8:2710.
41.?Hu DQ, Fan YY, Tan YL, Tian Y, Liu N, Wang L, Zhao DY, Wang C*, Wu AB*. Metabolic Profiling on Alternaria Toxins and Components of Xinjiang Jujubes Incubated with Pathogenic Alternaria alternata and Alternaria tenuissima via Orbitrap High-Resolution Mass Spectrometry. Journal of Agricultural and Food Chemistry 2017 Sep 27;65(38):8466-8474.
42.?Yang YX, Yu S, Tan YL, Liu N, Wu AB*. Individual and Combined Cytotoxic Effects of Co-Occurring Deoxynivalenol Family Mycotoxins on Human Gastric Epithelial Cells. Toxins 2017 Mar 9;9(3):96.
43.?Liu N, Nie DX, Tan YL, Zhao ZY, Liao YC, Wang H, Saeger SD, Wu AB*. An ultrasensitive amperometric immunosensor for zearalenones based on oriented antibody immobilization on a glassy carbon electrode modified with MWCNTs and AuPt nanoparticles. Microchimica Acta 2017 Jan;184(1):147-153.
44.?Shi W, Tan YL, Wang SX, Gardiner D, Saeger SD, Liao YC, Wang C, Fan YY, Wang ZP*, Wu AB*. Mycotoxigenic Potentials of Fusarium Species in Various Culture Matrices Revealed by Mycotoxin Profiling. Toxins 2016 Dec 26;9(1):6.
45.?Tian Y, Tan YL, Liu N, Yan Y, Liao YC, Chen J, Saeger SD, Yang H, Zhang QY, Wu AB*. Detoxification of Deoxynivalenol via Glycosylation Represents Novel Insights on Antagonistic Activities of Trichoderma when Confronted withFusarium graminearum. Toxins 2016 Nov 15;8(11):335.
46.?Tian Y, Tan YL, Liao YC, Sun CP, Wang SX, Wu AB*. Functional agents to biologically control deoxynivalenol contamination in cereal grains. Frontiers in Microbiology 2016 Mar 30;7:395.
47.?Liu N, Zhao ZY, Tan YL, Lu L, Wang L, Liao YC, Natalia B, Saeger SD, Zheng XD*, Wu AB*. Simultaneous raising of rabbit monoclonal antibodies to fluoroquinolones with diverse recognition functionalities via single mixture immunization. Analytical Chemistry 2016 Jan 19;88(2):1246-1252.
48.?Zhao ZY, Liu N, Yang LC, Wang JH, Song SQ, Nie DX, Yang XL, Hou JF, Wu AB*. Cross-linked chitosan polymers as generic adsorbents for simultaneous adsorption of multiple mycotoxins. Food Control 2015 Nov;57:362-369.
49.?Liu N, Nie DX, Zhao ZY, Meng XJ, Wu AB*. Ultrasensitive immunoassays based on biotin–streptavidin amplified system for quantitative determination of family zearalenones. Food Control 2015 Nov;57:202-209.
50.?Sun WS, Han Z, Johan A, Nie DX, Jin MT, Shi W, Zhao ZY, Saeger SD, Zhao Y*, Wu AB*. A reliable liquid chromatography–tandem mass spectrometry method for simultaneous determination of multiple mycotoxins in fresh fish and dried seafoods. Journal of Chromatography A 2015 Mar 27;1387:42-48.
51.?Song SQ, Liu N, Zhao ZY, Ediage E.M, Wu SL, Sun CP, Saeger SD, Wu AB*. Multiplex Lateral Flow Immunoassay for Mycotoxin Determination. Analytical Chemistry 2014 May 20;86(10):4995-5001.
著作
1.?真菌毒素與糧食食品安全/武愛波主編.--北京:科學(xué)出版社,2025.4(食品科學(xué)前沿研究叢書).--ISBN978-7-03-081898-0I.R996.2;TS201.6
中國國家版本館CP數(shù)據(jù)核字第2025JT7277號
2.?Aibo Wu, Food Safety & Mycotoxins, Springer, 2019.11.
DOI: https://doi.org/10.1007/978-981-32-9038-9
Print ISBN: 978-981-32-9037-2; Online ISBN: 978-981-32-9038-9
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